Intra-host Salmonella Typhi Model - scoping notes
Notes prepared from voice dictation with assistance of ChatGPT-4o.
Scope
These notes provide the skeleton of a model that aims to simulate within-host dynamics of Salmonella Typhi, connecting immune responses (especially antibody titers) to protection outcomes. It bridges vaccine efficacy and immunogenicity study field data and controlled human infection models (CHIM), and serves as the foundation for a next-generation Typhoid intrahost model suitable for generalizing across all exposure and immunological histories.